South America is a continent that truly has it all: epic landscapes, rich culture, mouthwatering food, and unforgettable adventures. If it’s your first time visiting, deciding where to start can feel overwhelming (there’s so much to see!). But don’t worry—We’ve got you covered. Here’s a list of the top 10 destinations you absolutely cannot miss on your first trip to South America.
1. Machu Picchu – Peru
This iconic Inca citadel is at the top of many bucket lists, and for good reason. Perched high in the Andes, Machu Picchu is a masterpiece of ancient engineering and offers views that will leave you breathless. Whether you hike the Inca Trail or take the scenic train ride, it’s an experience you’ll never forget.
Must-Do: Catch the sunrise at the Sun Gate for a magical view.
2. Cartagena - Colombia
This Caribbean gem is a feast for the senses. Stroll through the colorful streets of the walled city, soak up the sunshine on nearby beaches, and immerse yourself in Colombia’s vibrant culture. The mix of colonial architecture and tropical vibes is simply enchanting.
Must-Do: Take a sunset boat tour around Cartagena’s bay.
3. Patagonia – Argentina & Chile
For nature lovers, Patagonia is a dream come true. This remote region boasts dramatic landscapes, from glaciers and turquoise lakes to towering peaks and golden grasslands. Whether you visit Argentina’s El Calafate or Chile’s Torres del Paine, you’ll be amazed at every turn.
Must-Do: Trek the famous W Circuit in Torres del Paine.
4. Rio de Janeiro - Brazil
Rio is electric, energetic, and downright beautiful. From the world-famous Christ the Redeemer statue to the lively beaches of Copacabana and Ipanema, this city knows how to dazzle its visitors. Don’t forget to try the samba nightlife!
Must-Do: Take a cable car up Sugarloaf Mountain for stunning views of the city.
5. Salar de Uyuni – Bolivia
The world’s largest salt flat is a surreal destination that will make you feel like you’ve landed on another planet. During the rainy season, the flats transform into a giant mirror, creating mind-bending reflections. It’s pure magic.
Must-Do: Take a 4x4 tour and spend a night in a salt hotel.
6. Galapagos Islands – Ecuador
This UNESCO World Heritage Site is a wildlife lover’s paradise. Swim with sea lions, spot giant tortoises, and snorkel alongside tropical fish. The Galápagos Islands are a reminder of how beautiful and diverse our planet truly is.
Must-Do: Go island-hopping and snorkeling to see the rich marine life.
7. Buenos Aires - Argentina
Known as the “Paris of South America,” Buenos Aires is a city that dances to its own rhythm—literally. Tango performances, grand European-style architecture, and mouthwatering steak dinners are just the beginning of what this cosmopolitan city offers.
Must-Do: Attend a tango show in a historic milonga.
8. The Amazon Rainforest – Brazil, Peru, Colombia & More
The Amazon is the lungs of the planet and a must-visit for anyone craving adventure and wildlife encounters. Take a riverboat cruise, go on a jungle hike, and learn about indigenous cultures that call this incredible ecosystem home.
Must-Do: Take a guided night tour to see the jungle come alive.
9. Quito & The Middle of the World – Ecuador
Quito, Ecuador’s capital, sits high in the Andes and offers stunning views, a charming old town, and proximity to the Mitad del Mundo (Middle of the World) monument, where you can stand with one foot in each hemisphere!
Must-Do: Visit the equatorial line and test your balance on the famous "egg challenge."
10. San Pedro de Atacama – Chile
The driest desert in the world is a land of otherworldly beauty. From vast salt flats and geysers to starry night skies, San Pedro de Atacama is perfect for those who love unique and remote destinations.
Must-Do: Stargaze in the Atacama Desert, one of the best places in the world for astronomy.
